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Hib Vaccine

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Hib Vaccine, Haemophilus influenzae B Vaccine

  • Mechanism
  1. Conjugated protein Vaccine
  • Preparations
  1. Individual Vaccinations
    1. PRP-T (ActHIB or Hiberix)
    2. PRP-OMP (PedvaxHIB)
      1. Stronger immune response with first dose
      2. Preferred in high risk communities
        1. American Indian or Alaska native
        2. Asplenia or immunosuppression
  2. Standard Combination agents (most common delivery for U.S. Primary Series)
    1. DTaP/IPV/PRP-T (Pentacel)
    2. PRP-OMP/HepB (Comvax)
  3. Other combinations (limited use)
    1. Hib/MenCY (Menhibrix)
  • Primary Series
  1. Dose 1: Age 2 months
  2. Dose 2: Age 4 months
  3. Dose 3: Age 6 months
  4. Dose 4: Age 12 to 15 months
  • Efficacy
  1. Decreased Incidence by 99% since Hib Vaccination began in 1989
    1. Previously Hib was most common cause of Meningitis and invasive disease <5 years old
  • Adverse Effects
  1. No serious side effects
  2. Fever
  3. Irritability
  4. References
    1. (1996) MMWR Morb Mortal Wkly Rep 45(No. RR-12):1-35 [PubMed]