Platelet

Thrombocytopenia Causes

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Thrombocytopenia Causes, Low Platelet Causes

  • Causes
  • Common by Timing
  1. Acquired
    1. Infiltrative process
      1. Leukemia
      2. Histiocytosis
      3. Lymphoma
      4. Myelodysplastic Syndrome
      5. Myelofibrosis
      6. Storage disease
      7. Neuroblastoma
      8. Granulomatosis
      9. Osteopetrosis
    2. Suppression of Megakaryocytes (or Bone Marrow failure)
      1. Alcohol Abuse
      2. Radiation
      3. Infection
        1. Fetal TORCH Virus infection
        2. Cytomegalovirus
        3. Epstein-Barr Virus (Mononucleosis)
        4. Varicella Zoster Virus
        5. Hepatitis C virus
        6. HIV Infection
        7. Mumps
        8. Parvovirus B19
        9. Rickettsia
        10. Rubella
      4. Paroxysmal Nocturnal Hemoglobinuria
      5. Scwachman-Diamond Syndrome
      6. Medications
        1. See Drug induced Thrombocytopenia
        2. Alkylating Agents
        3. Antimetabolites
        4. Anticonvulsants
        5. Hydrochlorothiazide or other Thiazide Diuretics
        6. Estrogen
      7. Aplastic Anemia
  2. Hereditary
    1. Alport Syndrome
    2. Bernard-Soulier Syndrome
    3. Thrombocytopenia-absent radii (TAR syndrome)
      1. Autosomal Recessive trait
      2. Purpura immediately or within weeks of birth
    4. Fanconi Anemia
    5. Wiskott-Aldrich syndrome (x-linked condition)
      1. Decreased Platelets (Microthrombocytopenia)
        1. Adequate Megakaryocytes in Bone Marrow
      2. Eczematous Dermatitis
      3. Repeated infection (Immunodeficiency)
    6. May-Hegglin anomaly
      1. Increased Megakaryocytes
      2. Ineffective thrombopoiesis
    7. Congenital amegakaryocytic Thrombocytopenia
      1. Rare isolated newborn Thrombocytopenia
  • Causes
  • Platelet sequestration and miscellaneous causes