Pharm

Ximelagatran

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Ximelagatran, Exanta, Exarta

  • Background
  1. No longer available (off market in U.S.) due to hepatotoxicity
  2. Listed for historical reasons only
  1. Warfarin intolerant
  2. Patients with high risk of Intracranial Hemorrhage
  • Advantages
  1. As effective as Warfarin with INR 2-3
  2. Ximelagartan does not require monitoring
  3. Ximelagartan has fewer bleeding complications
  • Disadvantages
  1. Expensive
  2. Myocardial Ischemia risk
  3. Risk of severe liver toxicity
  • Dosing
  1. Studies used fixed dose of 36 mg bid