Pharm

Idarucizumab

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Idarucizumab, Praxbind

  • Mechanism
  • Pharmacokinetics
  1. Half-life: 1 hour
  2. Renally excreted
  • Efficacy
  1. Idarucizumab is highly effective (100%) in initial studies and FDA approval
  2. Complete Dabigatran reversal within minutes with effect lasting >24 hours, without Hypercoagulable adverse effects
  • Dosing
  1. Idarucizumab 5 gram IV
  • Disadvantages
  1. Expensive ($3500 wholesale in 2016)
  • Adverse Effects
  1. Thrombosis risk 6% at 30 days
  2. Mild adverse effects (Headache, skin and infusion site irritation)