Pharm

Edoxaban

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Edoxaban, Savaysa

  • Indications
  1. Atrial Fibrillation Anticoagulation
  2. Deep Vein Thrombosis
    1. However, must be started concurrently with Heparin, unlike other Factor Xa Inhibitors (Apixaban, Rivaroxaban)
  • Contraindications
  1. Creatinine Clearance <15 ml/min/1.73m2
  2. Creatinine Clearance >95 ml/min/1.73m2 (lower efficacy due to high drug clearance)
  3. Severe Cirrhosis (Child-Pugh Class C)
  • Dosing
  1. Standard dose: 60 mg orally daily
  2. Half dose indications (30 mg orally daily)
    1. Creatinine Clearance 15 to 50 ml/min/1.73m2 OR
    2. Weight <60 kg
  • Pharmacokinetics
  1. Oral bioavailability: 62%
  2. Half-life: 10-14 hours
  3. Onset: 1-2 hours
  4. Renal clearance 50%