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Andexxa

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Andexxa, Inactivated recombinant factor Xa

  • Background
  1. Planned release 2018 in U.S.
  • Mechanism
  1. Antidote for Eliquis (Apixaban) or Xarelto (Rivaroxaban), but not other Factor Xa Inhibitors
  2. Andexxa Binds Factor Xa Inhibitors
  • Efficacy
  1. Limits progression of bleeding within 12 hours of dose (onset as early as 1 hour)
  • Adverse Effects
  1. Expensive: $25,000 to 50,000 per patient
  2. Risk of Hypercoagulability complications (CVA, VTE)
  • References
  1. (2018) Presc Lett 25(7): 37-8