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Andexxa

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Andexxa, Andexanet Alfa, Inactivated Recombinant Factor Xa, Factor Xa Decoy

  • Background
  1. Released 2018 in U.S.
  • Mechanism
  1. Andexxa is a Inactivated Recombinant Factor Xa decoy protein that binds Factor Xa Inhibitors
  2. Factor Xa Inhibitors are not irreversibly bound, and rebound bleeding may occur after infusion
  3. Antidote studied for Eliquis (Apixaban) or Xarelto (Rivaroxaban)
    1. Thought to be effective for other Factor Xa Inhibitors (Edoxaban, Betrixaban)
  • Dosing
  1. Low Dose: 400 mg IV bolus (at 30 mg/min), followed by infusion at 4 mg/min for 2 hours
  2. High Dose: 800 mg IV bolus (at 30 mg/min), followed by infusion at 8 mg/min for 2 hours
    1. High dose indicated for Apixaban >5 mg/dose, Rivaroxaban 10 mg/dose or unknown dose
  • Efficacy
  1. Limits progression of bleeding within 12 hours of dose (onset as early as 1 hour)
  2. Excellent or good Hemostasis in 82% of patients in ANNEXa-4 study
  3. Ineffective in the 25% of patients who have low anti-Factor Xa Inhibitor
  • Adverse Effects
  1. Expensive: $25,000 to 50,000 per patient
  2. Risk of Hypercoagulability complications (CVA, VTE)
    1. Thrombosis risk at 30 days: 10%
  • References
  1. (2018) Presc Lett 25(7): 37-8
  2. Ebersole, Toomey and Baugh (2021) Crit Dec Emerg Med 35(5): 3-9
  3. Connolly (2019) N Engl J Med 380(14):1326-35 +PMID:30730782 [PubMed]