Lab
Mast Cell
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Mast Cell
See Also
Mastocytosis
Basophil
Immediate Hypersensitivity Reaction
Pathophysiology
Granulocyte
originating in the
Bone Marrow
, with peripheral target regions in the skin and connect tissue
High affinity for IgE and FceRI receptors
Functionally most similar to
Basophil
s, and primarily responds to
Immediate Hypersensitivity Reaction
Releases histamine (as well as other vasoactive
Cytokine
s and mediators stored in secretory granules)
Results in wheal and flare reaction
Red (vasodilation)
Edema
(vasodilation, vascular leak)
Labs
Morphology on Blood Smear
Diameter: 10-15 um
Bilobed or multi-lobed nucleus
Appearance dominated by the contained dense granules that stain purple
References
Mahmoudi (2014)
Immunology
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