Lab

Basophil Count

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Basophil Count, Basophil, Basophilia

  • Characteristics
  1. Forms in Bone Marrow from Myeloblasts as with other Granulocytes (Neutrophils, Eosinophils, Monocytes)
  2. Function: Allergic Response
    1. Similar mechanism of action to mast cells
    2. Related to delayed hypersensitivity response
    3. Triggered by IgE binding to antigen
    4. Releases inflammatory mediators
      1. Preformed mediators (e.g. Histamine, Bradykinin)
      2. New Mediators (e.g. Prostaglandins, Leukotrienes)
      3. Chemotactic factors attract Neutrophil, Eosinophil
  3. Morphology on Blood Smear
    1. Granulocyte cytoplasm stains darkly with Wright Stain
    2. Two lobed nucleus
  • Interpretation
  • Normal Levels
  1. Range: 0.4-1.0% (Least common Leukocyte)
  • Causes
  • Increased Basophils (Basophilia)
  1. Viral infections (e.g. Varicella)
  2. Hodgkin's Lymphoma
  3. Hemolytic Anemia
  4. Following splenectomy
  5. Myeloproliferative disease
    1. Chronic Myelogenous Leukemia
    2. Polycythemia Vera
    3. Myelofibrosis
  6. Inflammatory processes
    1. Inflammatory Bowel Disease
    2. Chronic dermatitis
    3. Asthma
    4. Chronic Sinusitis
  7. Endocrine causes
    1. Hypothyroidism
    2. Increased Estrogen
  • Causes
  • Decreased Basophils