Histiocytosis
Hand-Schuller-Christian Syndrome
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Hand-Schuller-Christian Syndrome
, Histiocytosis X, Lipoid Histiocytosis
See Also
Langerhans Cell
Granuloma
tosis
Symptoms
Sore
Oral Mucosa
Skin Eruption
Signs
Classic Triad (10%)
Lytic bone lesions (esp.
Skull
defects)
Diabetes Insipidus
Exophthalmos
Oral Changes
Gum swelling and necrosis
Extrusion of teeth
Rash
Papular, seborrheic or petechial rash
Minute xanthomatous
Nodule
s
Raised yellow to brown lesions in neck and axilla
Growth retardation
Developmental Delay
Lung
changes
See
Pulmonary Histiocytosis X
Labs
Complete Blood Count
Hemoglobin
or
Hematocrit
consistent with
Anemia
White Blood Cell Count
consistent with
Leukopenia
Platelet Count
consistent with
Thrombocytopenia
Chemistry panel and Serum osmolarity
Diabetes Insipidus
changes
Diagnosis
Skin biopsy
Bone Marrow Biopsy
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