Exam

Intrinsic Clotting Pathway

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Intrinsic Clotting Pathway, Intrinsic Clotting Cascade

  • Pathophysiology
  1. Initiated by negatively charged surface
  • Physiology
  • Pathway
  1. Factor XII converted to Factor XIIa
    1. Cofactors
      1. PK
      2. HMWK
    2. Inhibitors
      1. Heparin
      2. Antithrombin III
  2. Factor XI converted to Factor XIa
  3. Factor IX converted to Factor IXa
    1. Cofactors:
      1. Factor VIII
      2. von Willebrand's factor (vWF) carries Factor VIII
    2. Inhibitors
      1. Protein C
      2. Protein S
  4. Factor X converted to Factor Xa
  5. Joins Common Clotting Pathway