Coags
Factor V Leiden
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Factor V Leiden
, Factor 5 Leiden, Activated Protein C resistance, APC Resistance
Epidemiology
Responsible for 20-50% of
Hypercoagulable
patients
Incidence
of
Autosomal Dominant
genetic defect
Europeans: 15%
North America: 3-5%
Risks
Heterozygote
: 5-10 times the risk of thrombosis
Homozygote
: 50-100 times the risk of thrombosis
Pathophysiology
Factor V is a
Cofact
or for Factor X
Defect prevents Factor V degradation by Protein C
Labs
Activated Protein C (APC) resistance
Can not be anticoagulated when this lab run
PCR for Factor V Leiden
Responsible for 95% of APC Resistance
Does NOT require that patient be off
Anticoagulation
Complications
Deep Vein Thrombosis
Pulmonary Embolism
Myocardial Infarction
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