Coags

Antithrombin III deficiency

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Antithrombin III deficiency

  • Pathophysiology
  1. Antithrombin III normally inhibits
    1. Factor IXa
    2. Factor Xa
    3. Factor XIa
    4. Factor XIIa
    5. Thrombin
  2. Enhanced by Heparin
  • Epidemiology
  1. Heterozygotes have 25-50% ATIII functional levels
  2. First episode of thrombosis occurs ages 10-30 years
  • Complications
  1. Venous Thromboembolism
  • Labs
  1. Functional level Antithrombin III