Coags
Antithrombin III deficiency
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Antithrombin III deficiency
Pathophysiology
Antithrombin III
normally inhibits
Factor IX
a
Factor X
a
Factor XI
a
Factor XII
a
Thrombin
Enhanced by
Heparin
Epidemiology
Heterozygote
s have 25-50% ATIII functional levels
First episode of thrombosis occurs ages 10-30 years
Complications
Venous Thromboembolism
Labs
Functional level
Antithrombin III
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