Pharm
Non-Nucleoside Reverse Transcriptase Inhibitor
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Non-Nucleoside Reverse Transcriptase Inhibitor
, NNRTI
See Also
Anti-Retroviral Therapy
Mechanism
Bind directly to reverse transcriptase
Prevents RNA conversion to DNA
Completely different mechanism than
nRTI
Preparations
First
Gene
ration
Delavirdine (Rescriptor)
Efavirenz
(
Sustiva
, EFV)
Nevirapine
(
Viramune
, NVP)
Preparations
Second
Gene
ration
Etravirine
(
Intelence
)
Approved in treatment experienced patients
Rilpivirine (Endurant)
FDA approved in 2011 for treatment-naive patients
Adverse Reaction
See specific agents
Hyperlipidemia
Rash is common (especially with
Nevirapine
)
More common and more severe in women
Reduced
Incidence
if start dose slowly over 2 weeks
Prophylaxis not recommended (e.g.
Corticosteroid
s)
Antinori (2001) AIDS 15:1579-81 [PubMed]
Switching to a different drug class may be needed
My progress to
Stevens-Johnson Syndrome
,
Toxic Epidermal Necrolysis
,
Erythema Multiforme
Severe rash is especially more common with
Etravirine
and especially in women
References
(2009) Treat Guidel Med Lett 7(78): 11-22 [PubMed]
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