Pharm

Integrase Strand Transfer Inhibitor

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Integrase Strand Transfer Inhibitor, Integrase Inhibitor, Raltegravir, Isentress, InSTI, RAL, Bictegravir, Biktarvy, Dolutegravir, Tivacay

  • Class
  1. Anti-retroviral agent
  2. Integrase Strand Transfer Inhibitor
  • Mechanism
  1. Integrase Strand Transfer Inhibitor prevents viral DNA from integrating into host DNA
    1. Blocks the integrase enzyme
  • Indications
  1. Anti-retroviral naive patients
  2. Anti-retroviral experienced patients
  • Preparations
  1. Bictegravir (Biktarvy)
  2. Dolutegravir (Tivacay)
  3. Raltegravir (Isentress)
    1. Dose: One 400 mg tablet orally twice daily
  • Efficacy
  1. Drug resistance is common
  • Adverse Effects
  • Raltegravir
  • Drug Interactions
  1. Typically fewer Drug Interactions than other Anti-Retroviral Agents
  2. Phenytoin
  3. Rifampin
  4. St John's Wort
  5. Avoid taking at the same time as calcium, Magnesium, aluminum and iron containing agents