Pharm

Abacavir

search

Abacavir, Ziagen

  • Contraindications
  1. HLA-B*5701 positive state (screen in advance of starting)
    1. Associated with life-threatening hypersensitivity
  • Dosing
  1. Abacavir 300 mg PO bid
  • Precautions
  1. Do not use unless patient is negative for HLA-B5701
    1. Risk of Hypersensitivity Reaction if HLA-B5701 positive
    2. Lucas (2007) J Antimicrob Chemother 59(4):591-3 +PMID:17317695 [PubMed]
  • Adverse Effects
  1. Hypersensitivity (3%)
    1. Presents with Fever and Rash
    2. Associated with HLA-B*5701 positive state
    3. Mean onset 11 days after start
    4. Lethal reaction if restarted after reaction (50%)
    5. Never rechallenge Abacavir after reaction
  2. Cardiovascular risk
    1. Unclear association is being investigated
  • Resources
  • Abacavir Hypersensitivity Registry
  1. Phone: 1-800-270-0425