Pharm
Yasmin
search
Yasmin
, Drosperinone, Yaz, Yasminelle, Ocella, Zarah
See Also
Oral Contraceptive
Progestin
Indications
Contraception
Contraindications
Renal Insufficiency
Hepatic insufficiency
Adrenal Insufficiency
Mechanism
Drosperinone
Newer synthetic
Progestin
Antiandrogenic activity similar to
Progesterone
Lowest
Androgenic Activity
Marginal benefit over other low androgen OCPs
Antimineralcorticoid effect (Related to
Spironolactone
)
Only OCP
Progestin
with antimineralcorticoid activity
Drospirenone 3 mg is equivalent to 25 mg
Spironolactone
Efficacy
Similar to other
Oral Contraceptive
s
Formulations
Yaz (3/20 with 24 days and 4
Placebo
days)
Yasminelle (3/20 with 21 days and 7
Placebo
days)
Yasmin, Ocella or Zarah (3/30)
Drug Interactions
Potassium
retention effects
Potassium
sparing
Diuretic
s (e.g.
Spironolactone
)
ACE Inhibitor
s
Angiotensin Receptor Blocker
s
Aldosterone Antagonist
s
Heparin
Nonsteroidal Anti-inflammatory
drugs
Monitoring
Serum Potassium
in first month
Indicated if concurrent use of drugs listed above
Adverse Effects
See
Oral Contraceptive
Potassium
retention (see above)
May be associated with higher
Thromboembolism
risk
Advantages
May be associated with less weight gain than other OCP
As effective as other OCPs in
Acne Vulgaris
May be useful in
Polycystic Ovary Disease
Spironolactone
used for associated
Hirsutism
References
(2002) Med Lett Drugs Ther 44(1133):55-7 [PubMed]
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