Pharm

Provera

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Provera, Medroxyprogesterone

  • Dosing
  1. Amenorrhea
    1. Sequential: 5 to 10 mg qd for 5-10 days
    2. Continuous: 2.5 mg qd
  2. Dysfunctional Uterine Bleeding (DUB)
    1. Sequential: 5-10 mg qd for 5-10 days, start on Day 16
  3. Postmenopausal Estrogen Replacement (with Premarin)
    1. Sequential: 2.5 to 5 mg PO qd for last 10 cycle days
    2. Continuous: 5 to 10 mg qd
  • Adverse effects
  1. Major Depression
  2. Breakthrough bleeding
    1. Increasing dose to 20-30 mg qd may reduce bleeding
      1. However may have increased risk
      2. Long term lipid and cardiovascular effects?