Pharm

Gonadotropin-releasing Hormone Agonist

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Gonadotropin-releasing Hormone Agonist, GnRH agonist, Nafarelin Acetate, Synarel

  • Indication
  • Pathophysiology
  1. Potentiates Gonadotropin-releasing hormone (GnRH)
  2. Results in hypoestrogenism or pseudo-Menopause
  3. Does not cause the same androgenic effects as Danazol
  • Dosing
  • Nafarelin Acetate (Synarel)
  1. Synarel 200-400 micro-g intranasally bid
  • Efficacy
  1. Effective at regression of lesions and relief of pain
  2. No proven effect on fertility
  • Adverse effects
  1. Menopausal symptoms
    1. Hot Flashes
    2. Insomnia
    3. Emotional changes
  2. Bone density loss with prolonged use