Pharm

First Generation Progestin

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First Generation Progestin, Norethindrone, Norethynodrel

  • Class
  1. 19 Nor-Testosterone Progestin: Estrane
  • Norethindrone
  1. Relative Progestational Activity: 1.0
    1. Estrogenic Activity: 1.0
    2. Androgenic Activity: 1.0
    3. Endometrial Activity: 1.0
    4. Anti-Estrogen: Active
  2. Preparations
    1. Ethinyl Estradiol
      1. Brevicon or Modicon (0.5/35)
      2. Ovcon (0.4/35, 1/50)
      3. Norinyl or Ortho-Novum 1/35
      4. Ortho-Novum 10/11 Biphasic (0.5-1.0/35)
      5. Ortho-Novum 7/7/7 Triphasic (0.5-0.75-1.0/35)
      6. Tri-Norinyl Triphasic (0.5-1.0-0.5/35)
    2. Mestranol (50 mcg is equivalent to 35 mcg estradiol)
      1. Norinyl 1/50
      2. Ortho-Novum 1/50
      3. Necon 1/50
      4. Norinyl-1 (UK)
    3. Progestin-only (Mini-Pill)
      1. Micronor, Nor-QD (0.35)
  • 50 µg Mestranol (equivalent to 35 µg Ethinyl Estradiol)
  • 1000 µg Norethindrone (UK
  • Norinyl-1, Pfizer; US: Ortho-Novum 1/50; Ortho-McNeil; Norinyl 1/50, Watson; Necon 1/50, Watson)
  • Norethynodrel
  1. Relative Progestational Activity: 0.3
    1. Estrogenic Activity: 8.3
    2. Androgenic Activity: 0
    3. Endometrial Activity: 0
    4. Anti-Estrogen: Inactive
  2. Preparations (MestranolEstrogen component)
    1. Enovid 5 (5/75)
    2. Enovid E (2.5/100)