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BRCA2

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BRCA2

  • Location
  1. Chromosome 13
  • Epidemiology
  1. Responsible for a third of hereditary Breast Cancer
  2. Affects Male as well as Female members
  3. Defective gene connotes:
    1. Ovarian Cancer risk: 15-20% (less than BRCA1)
    2. Breast Cancer risk: 90%
      1. Age 20-29: Relative Risk Breast Cancer 46
      2. Age 30-39 Relative Risk Breast Cancer 38
      3. Age 40-49: Relative Risk Breast Cancer 13
      4. Age 50-59: Relative Risk Breast Cancer 9.8
      5. Age 60-69: Relative Risk Breast Cancer 2.1
      6. Chen (2006) j clin oncol 24(6): 863-71 [PubMed]
      7. Metcalfe (2018) Clin Genet 93(5): 1063-8 [PubMed]
  • References
  1. (1994) Science 265:2088 [PubMed]
  2. (1995) Lancet 346:544 [PubMed]
  3. Khan (2020) Am Fam Physician 103(1): 33-41 [PubMed]