Pharm
Prochlorperazine
search
Prochlorperazine
, Compazine
Indications
Nausea
or
Vomiting
Migraine Headache
Motion Sickness
Vertigo
Hiccup
s
Mechanism
Phenothiazine Antiemetic
Dopamine
2 Antagonist
Adverse effects
Orthostatic Hypotension
Extrapyramidal Reaction
Precaution
Reactions may be delayed up to 2 weeks after dose
Reactions
Akathisia
(25-60% after single dose)
Dystonic Reaction
(4% after a single dose)
Olsen (2000) Am J Emerg Med 18(5): 609-11 +PMID:10999579 [PubMed]
Drotts (1999) Ann Emerg Med 34(4 Pt 1): 469-75 [PubMed]
Concurrent
Diphenhydramine
(
Benadryl
) prevents
Akathisia
(NNT 5, ARR 22%)
Diphenhydramine
(
Benadryl
) 50 mg IV (adults) was the dose used in study
Vinson (2001) Ann Emerg Med 37(2):125-31 +PMID:11174228 [PubMed]
Dosing
Adults
Compazine 5-10 mg PO/IV/IM q6-8 hours
Compazine 25 mg PR q12 hours
Sustained release Compazine 15 mg PO qam or 10 mg bid
Children (over age 2 years or >10 kg)
Compazine 0.1 mg/kg/dose PO/PR q6-8 hours
Compazine 0.1 to 0.15 mg IM q6-8 hours
Precautions
IV dosing must be administered over 2 minutes or more
Lowers
Seizure
threshold
Efficacy
Better
Antiemetic
than
Phenergan
in ER patients
Ernst (2000) Ann Emerg Med 36(2): 89-94 [PubMed]
References
Johnson (1993) Harriet Lane, Mosby, p. 521
(2002) Tarascon Pocket Pharmacopoeia, p. 67
Olsen (2000) Am J Emerg Med 18(5):609-11 [PubMed]
Vinson (2001) Ann Emerg Med 37(2):125-31 [PubMed]
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