Pharm

Misoprostol

search

Misoprostol, Cytotec, PGE1 Gel

  • Mechanism
  1. Gastric Mucosa Protection by prostaglandin replacement
  • Preparations
  1. Misoprostol (Cytotec)
  • Indication
  1. Peptic Ulcer Disease prevention
    1. Prevents ulcers in those on NSAIDs chronically
  2. Cervical Ripening agent in Pregnancy Labor Induction
  • Dosing
  1. See Cervical Ripening for pregnancy dosing
  2. Option 1: 100 ug qid with food
  3. Option 2: 200 ug bid with food
    1. Better tolerated than qid dosing
  • Side Effects
  1. Diarrhea
  2. Poorly tolerated
  1. Dosing qid: 4% Peptic Ulcer Disease recurrence
  2. Dosing bid: 8% Peptic Ulcer Disease recurrence
  3. Placebo: 16% Peptic Ulcer Disease recurrence
  4. Reference
    1. Raskin (1995) Ann Intern Med 123:344-50 [PubMed]