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Hepatitis E

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Hepatitis E, HEV

  • See Also
  • Epidemiology
  1. Enteric transmission of non-A, non-B Hepatitis
    1. Most common cause in world
  2. Waterborne Illness epidemics in
    1. India
    2. Asia
    3. Africa
    4. Mexico
  • Course
  1. Self-limited illness
  2. Mortality 10-20% in pregnant women
  3. No associated chronic hepatitis
  • Pathophysiology
  1. Incubation period: 15-60 days (mean 40 days)
  2. Infectivity: Virus excretion in stool for <14 days
  3. Calicivirus (diameter 32-34 nm))
  • Signs and Symptoms
  • Differential Diagnosis
  • Management
  1. High calorie diet (better tolerated in morning)
  2. IV Hydration when indicated for severe dehydration
  3. Cholestyramine up to 4g PO qid for severe Pruritus
  4. Avoid drugs with hepatic metabolism