Lab

Liver Function Test

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Liver Function Test, LFT

  • Labs
  • Markers of liver function and protein synthesis
  • Labs
  • Markers of hepatocellular disease
  1. Alanine Aminotransferase (ALT)
    1. Most specific for hepatocyte injury
  2. Aspartate Aminotransferase (AST)
    1. Less specific than ALT (present outside liver)
  3. AST to ALT ratio
    1. Most liver conditions (e.g. NASH): Ratio <1
    2. Alcoholism: Ratio >2
    3. Wilson's Disease >4
  4. Lactate Dehydrogenase (LDH)
    1. Least specific for hepatocyte injury
    2. Dramatically increased in ischemic hepatitis
    3. Increased with alk phos in liver metastases
  • Labs
  • Disease specific markers
  1. Definite value
    1. Viral Hepatitis Serology
    2. Iron studies
    3. Ceruloplasmin (Wilson's Disease)
  2. Limited value: Anti-Smooth muscle Ab
    1. Antimitochondrial Antibody
    2. Alpha-1 antitrypsin