Lab
Helicobacter pylori Stool Antigen
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Helicobacter pylori Stool Antigen
, H. pylori Stool Antigen, HpSA
See Also
Helicobacter pylori Noninvasive Testing
Indications
Dyspepsia
evaluation
Confirmation of cure after
H. pylori
management
Mechanism
Measures
H. pylori
Antigen
present in stool sample
Efficacy
Stool
monoclonal
Antigen
tests (enzyme immunoassay)
Test Sensitivity
: 92%
Test Specificity
: 94%
Most accurate, but more expensive than immunochromatography
Stool
monoclonal
Antigen
tests (Immunochromatography)
Test Sensitivity
: 69-87%
Test Specificity
: 87-93%
Variable reliability, but available for office based testing
Accurate for confirmation of cure at 7 days
Antigen
levels significantly suppressed with cure
Vaira (2002) Ann Intern Med 136:280-7 [PubMed]
Protocol
Patient stops medications 2 weeks before test
Stop
Proton Pump Inhibitor
s (but less affected than
Urea Breath Test
)
Stop all antibiotics
Stop bismuth compounds (e.g. Pepto Bismol)
Advantages
Excellent first line non-invasive test for diagnosis
Noninvasive test of
H. pylori
cure
Inexpensive
References
Calvet (2009) Clin Infect Dis 48(10): 1385-91 +PMID:19368506 [PubMed]
Cutler AF (1995) Gastroenterology 109:136-41 +PMID:7540995 [PubMed]
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