Lab

Helicobacter pylori Invasive Testing

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Helicobacter pylori Invasive Testing, H. pylori culture, Endoscopic Biopsy for H. pylori, Rapid Urease Test, CLO Test

  • Indications
  1. Dyspepsia evaluation
  • Tests
  1. Gastric Biopsy with Steiner's Stain
    1. Test Sensitivity: 95%
    2. Test Specificity: 99-100%
  2. Rapid Urease Test (e.g. CLO Test)
    1. Test Sensitivity: 93-97%
    2. Test Specificity: >95%
  3. H. pylori culture
    1. Test Sensitivity: 70-80%
    2. Test Specificity: 100%
  • Advantages
  1. Gold standard for H. pylori diagnosis
  2. Confirms cure for H. pylori
  • Disadvantages
  1. Requires endoscopic biopsy
  2. Sensitivity altered for histology and urease activity
    1. Proton Pump Inhibitors
    2. Antibiotics
    3. Bismuth