Pharm

Intraocular Parasympathomimetic

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Intraocular Parasympathomimetic, Intraocular Cholinergic, Ocular Parasympathomimetic Agent, Miotic, Intraocular Pilocarpine, Isoptocarpine, Pilopine gel, Ocusert, Carbachol, Echothiophate, Phospholine Iodide, Isopto Carbachol, Pilocar

  • Indication
  1. Open Angle Glaucoma second line agent (adjunctive)
  • Mechanism
  1. Reduces resistance to aqueous outflow
  • Preparations
  1. Pilocarpine (Isoptocarpine, Pilopine gel, Ocusert, Pilocar) 1 drop four times daily
  2. Carbachol (Isopto Carbachol)
  3. Echothiophate (Phospholine Iodide)
  • Adverse Effects
  1. Generally well tolerated
  2. Pupil Constriction (primary expected effect)
  3. Systemic effects (if absorbed)
    1. Nausea or Vomiting
    2. Diarrhea
    3. Sweating
    4. Tremor
    5. Hypotension
    6. Sinus Bradycardia
    7. Atrioventricular Block