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Medications Affecting Thyroid Function

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Medications Affecting Thyroid Function, Drug-Induced Thyroiditis

  1. Excess Thyroid hormone intake
  2. Excess Iodine exposure
    1. Dietary Iodine
    2. Radiocontrast Material (contains Iodine)
    3. Amiodarone (contains 37% Iodine)
  1. Amiodarone
    1. Type 1 Amiodarone-induced Thyrotoxicosis
      1. Increased Thyroid hormone synthesis (pre-existing Goiter)
      2. Treated with antithyroid medications (and Beta Blockers as needed for symptom control)
    2. Type 2 Amiodarone-induced Thyrotoxicosis
      1. Destructive Thyroiditis results in increased T4 and T3 release into circulation
      2. Treated with Glucocorticoids (and Beta Blockers as needed for symptom control)
  2. Denileukin (Ontak)
    1. CD25 cytotoxin used in CTCL, CLL, Psoriasis causes Hyperthyroidism
  3. Interferon-alfa
    1. Autoimmune mechanism causes Thyroiditis with Hypothyroidism or Hyperthyroidism
  4. Interleukin-2
    1. Autoimmune mechanism causes Thyroiditis with Hypothyroidism more often than Hyperthyroidism
  5. Lithium
    1. Autoimmune mechanism causes Thyroiditis with Hypothyroidism more often than Hyperthyroidism
  6. Tyrosine Kinase inhibitors
    1. Thyroid uptake inhibition results in Hypothyroidism