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C1 Human Esterase Inhibitor

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C1 Human Esterase Inhibitor, C1 Antagonist, C1 Inhibitor, Berinert

  • See Also
  1. Angioedema
  2. Bradykinin Receptor Antagonist
  • Indications
  1. Severe, airway compromising Angioedema
    1. Hereditary Angioedema (treatment of choice)
    2. ACE InhibitorAngioedema (may be effective)
  • Dose
  1. Berinert 20 IU/kg IV for 1 dose
  2. Cost: $3000 per dose
  • Adverse Effects
  1. Headache (common)
  2. Nausea (common)
  3. Dizziness
  4. Fever
  5. Local skin reaction and Rash
  6. Flu-like symptoms
  7. Hypersensitivity Reaction (uncommon)
  8. Thrombotic event, especially at doses higher than recommended (uncommon)
  • References
  1. (2015) Lexicomp, accessed online 4/9/2015
  2. Farkas (2007) J Allergy Clin Immunol 120(4):941-7 +PMID:17761272 [PubMed]