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Adverse Drug Reaction

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Adverse Drug Reaction, Medication Hypersensitivity, Drug Reaction

  • Risk factors
  • Immune-mediated Drug Reaction
  1. Drug Hypersensitivity Reaction to related medication
  2. Adults (especially women)
  3. Concurrent viral infection
  4. Comorbid condition
    1. HIV Infection
    2. Asthma
    3. Systemic Lupus Erythematosus
    4. Beta Blocker use
  5. Medications with larger more complicated structure
    1. Non-human proteins
    2. Streptokinase
    3. Insulin
  • Findings
  • Suggestive of drug hypersensitivity
  • Management
  1. Avoid drug responsible for adverse reaction
  2. Consider testing for allergy if suspect immune-mediated
    1. Type 1 Hypersensitivity Reaction
      1. Skin Testing
      2. RAST Testing
    2. Type 2 Hypersensitivity Reaction
      1. Coombs' Test positive
      2. Complete Blood Count
        1. Hemolytic Anemia
        2. Thrombocytopenia
        3. Neutropenia
    3. Type 3 Hypersensitivity Reaction
      1. Erythrocyte Sedimentation Rate (ESR) increased
    4. Type 4 Hypersensitivity Reaction
      1. Patch Testing
  3. Consider desensitization to offending agent
  4. Consider specific agent management
    1. Penicillin Adverse Drug Reaction
    2. Intravenous Contrast