Allergy

Autoimmunity

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Autoimmunity, Autoimmune Condition, Autoimmune Disease

  • Epidemiology
  1. Women account for 75% of Autoimmunity
  2. Age of onset is most common in young adult women
  • Mechanism
  1. Autoantibody, T-Cell mediated self tissue destruction
  2. Predisposing factors
    1. Autoimmunity increases with age: lower self tolerance
    2. Genetic predisposition
  3. Protective factors
    1. Autoimmunity less common where high antigen exposure
    2. Protective exposures in first year of life
      1. Eating dirt
      2. Living on a farm
      3. House pet
      4. Day care
    3. References
      1. Weiss (2002) N Engl J Med 347:930 [PubMed]
  • Associated Conditions
  • Dermatologic Autoimmune Conditions
  • Associated Conditions
  • Gastrointestinal Autoimmune Conditions
  • Associated Conditions
  • Hematologic Autoimmune Conditions
  • Associated Conditions
  • Neurologic Autoimmune Conditions
  • Associated Conditions
  • Vascular Autoimmune Conditions
  • References
  1. Zuber (2003) AAFP Board Review, Seattle