Pharm

Pyrethrin

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Pyrethrin, RID, A-200, Piperonyl butoxide

  • Background
  1. Extract from chrysanthemums
  2. Pyrethroids are longer acting derivatives (Permethrin)
  3. Pesticide Agents related to Pyrethrins
    1. Allethrin
    2. Cyfluthrin
    3. Cypermethrin
    4. Deltamethrin
    5. Dimethrin
    6. Fenothrin
    7. Fenvalerate
    8. Permethrin
    9. Remethrin
  • Indications
  • Advantages
  1. Available without a prescription
  2. Convenient (only 10 minute application)
  • Disadvantages
  1. Does not kill all unhatched eggs
  2. Requires repeat application in 5-7 days
  3. Treatment failures are common
  • Directions for treatment of Lice
  1. Apply Shampoo to involved area
  2. Wash after 10 minutes
  3. Reapply Shampoo in 5-7 days
  • Preparations
  1. Bottles of 60, 120, 240 ml
  • Adverse Effects
  1. Mechanism
    1. Nerve toxicity is rare in humans
    2. Minimal absorption and rapid hepatic metabolism
  2. Effects
    1. Allergic Reaction in 1-3%
      1. Nasal congestion
      2. Asthma exascerbation
    2. Topical effects
      1. Paresthesias (hands and face)
    3. Rare neurologic effects
      1. Seizures
      2. Tremor
      3. Incoordination