Pharm

Drug-Induced Pemphigus

search

Drug-Induced Pemphigus, Drug-Triggered Pemphigus

  • Mechanism of Drug-Induced Pemphigus
  1. Sulfhydryl groups lyse disulfide bonds
  2. Results in Blister formation
  • Causes of Drug-Induced Pemphigus
  • Signs of Drug-Induced Pemphigus
  1. Pemphigus follows medication use of >2 month duration
  2. Similar to Superficial Pemphigus (Pemphigus Foliaceus)
    1. Most cases are mild
  • Differential Diagnosis of Drug-Induced Pemphigus
  1. Erythema Multiforme
  2. Drug-Triggered Pemphigus (unmasks Pemphigus Vulgaris)
    1. Rifampin
    2. Penicillin
    3. Cephalexin
    4. Progesterone
    5. Gold
    6. Piroxicam
    7. Phenobarbital
  • Course
  1. Drug-Induced Pemphigus
    1. Remits with stopping medication in 40-50% of cases
    2. May follow severe course in some cases
  2. Drug-Triggered Pemphigus
    1. Does not remit
    2. Follows course of Pemphigus Vulgaris