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Pemphigoid Gestationis

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Pemphigoid Gestationis, Herpes Gestationis

  • Pathophysiology
  1. Autoimmune skin disorder
  2. Associated with HLA-DR3, and HLA-DR4
  • Associated conditions
  1. Grave's Disease
  2. Choriocarcinoma or Molar Pregnancy (rare)
  • Signs
  1. Vesicles and bullae form on Abdomen, extremities
  • Management
  1. Increased antepartum observation
  2. Oral Antihistamines
  3. Topical Corticosteroids
  4. Systemic Corticosteroids in severe cases
  • Complications
  1. Preterm delivery
  2. Small for Gestational Age infant
  • Course
  1. Onset in second-half of pregnancy
  2. Improves in late pregnancy
  3. May be exacerbated in early postpartum period
  4. May recur in future pregnancies