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Hyperpigmentation in Pregnancy

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Hyperpigmentation in Pregnancy, Chadwick's Sign, Linea Nigra

  • Physiology
  1. Melanocyte stimulating hormone rises in early pregnancy
  2. Increased Melanin deposition
  1. Scarred areas and nevi darken
  2. Pigmented areas become more pigmented
    1. Areola
    2. Axilla
    3. External genitalia
    4. Anal region
    5. Linea Nigra
  • Signs
  • Specific
  1. Chadwick's Sign
    1. Darkened vulva and vagina
  2. Melasma or Chloasma (Mask of pregnancy)
    1. Dark areas under eyes and bridge nose
  3. Linea Nigra
    1. Dark midline low Abdomen