Pharm

Sotalol

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Sotalol, Betapace

  • Indication
  1. Ventricular Arrhythmia
  2. Supraventricular Arrhythmia
    1. Atrial Fibrillation Cardioversion
      1. Time to Cardioversion: 3-6 hours
      2. Conversion Rate: 20-52%
      3. Chronic Efficacy: 50-60%
  • Mechanism
  1. Class III Antiarrhythmic
    1. Prolongs action potential duration
    2. Increases cardiac tissue refractoriness
  2. Class II Antiarrhythmic
    1. Non-selective Beta Blocker
  • Adverse Effects
  1. Bradycardia
  2. Hypotension
  3. Proarrhythmia (Torsades de Pointes)
    1. Associated with doses over 320 mg per day
  • Dosing
  • Oral
  1. Starting Dose: 80 mg PO bid
  2. Typical dosing: 80-160 mg PO bid
  3. Maximum: 640 mg per day