Pharm

Sodium Channel Blocker

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Sodium Channel Blocker

  • Causes
  • Cardiovascular
  1. Antiarrhythmics
    1. See Sodium Channel Blockade Antiarrhythmics
    2. Class Ia: Lengthens Action Potential duration
      1. Quinidine
      2. Procainamide (Pronestyl)
      3. Disopyramide (Norpace)
      4. Amiodarone (also Class II, III, IV)
      5. Ajmaline (used to diagnostically provoke Arrhythmia in suspected Brugada Syndrome)
    3. Class Ib: Shortens Action Potential duration
      1. Lidocaine (Xylocaine)
      2. Tocainide (Tonocard)
      3. Mexiletine (Mexitil)
      4. Aprindine
    4. Class Ic: Slows conduction
      1. Flecainide (Tambocor)
      2. Encainide (Enkaid)
      3. Propafenone (Rythmol)
      4. Moracizine (Ethmozine, off U.S. market in 2007)
  2. Diuretic
    1. Triamterene
    2. Amiloride
  3. Beta-Blockers (esp. non-selective)
    1. Acebutolol
    2. Oxprenolol
    3. Propranolol
  • Causes
  • Miscellaneous
  • Resources
  1. Sodium Channel Blocker Toxicity (Internet Book of Critical Care)
    1. https://emcrit.org/ibcc/nacb/