Pharm
Nicardipine
search
Nicardipine
See Also
Hypertensive Emergency
Intravenous Antihypertensive
Dihydropyridine Calcium Channel Blocker
Clevidipine
Indications
First-line management of
Hypertensive Emergency
(
Hypertensive Crisis
)
Preferred over
Labetalol
,
Nitroglycerin Drip
, and
Nitroprusside
Use
Esmolol
in
Hypertensive Crisis
if
Heart Rate
control is needed (e.g. AAA or
Aortic Dissection
)
Mechanism
Second
Gene
ration
Dihydropyridine Calcium Channel Blocker
Pure arterial vasodilation
Decreases
Blood Pressure
Does not effect
Heart Rate
or
Preload
Dosing
Start: 5 mg/hour
Maximum: 15 mg/hour
Titrate
Increase by 2.5 mg/hour every 5-15 minutes until
Blood Pressure
goal reached or maximum reached (15 mg/hour)
Once goal
Blood Pressure
achieved, titrate down towards 3 mg/hour as long as
Blood Pressure
is controlled
Adverse Effects
See
Calcium Channel Blocker
References
Orman and Weingart in Majoewsky (2012) EM:RAP 12(2): 6-7
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