Pharm

Long Acting Nitroglycerin

search

Long Acting Nitroglycerin, Long Acting Nitrates, Transdermal Nitroglycerin, Transdermal Glyceryl Trinitrate, Isosorbide, Nitroglycerin Ointment, Isosorbide Mononitrate, Isosorbide Dinitrate

  • General
  1. Need 10-12 hours Nitroglycerin free interval per day
  2. Not proven to reduce Incidence of future events
  • Indications
  1. Chronic Angina Pectoris
  2. Not indicated for acute Myocardial Ischemia
  • Preparations
  • Long acting
  1. Isosorbide Dinitrate (Isordil)
    1. Reg: 10 to 40 mg PO tid (7am, 12 noon, 5pm)
    2. SR: 40-80 mg PO bid (8am, 3pm)
  2. Isosorbide Mononitrate
  3. Nitroglycerin sustained release (Nitro-Bid)
  • Preparations
  • Transdermal
  1. Nitroglycerin 2% ointment (15 mg per inch)
    1. Start: 0.5 inch q8 hours
    2. Maintenance: 1-2 inches q8 hours
    3. Maximum: 4-5 inches q4 hours
    4. Poor absorption, with dosing at 1 inch equivalent to 10 mcg/min IV infusion
    5. Other preparations are preferred
  2. Transdermal Nitroglycerin
    1. Apply 1 patch for 12-14 hours per day
    2. Doses range from 0.1 to 0.8 mg per hour