Labetalol, Trandate

  • Indications
  1. Refractory Hypertension
    1. Very effective outpatient agent in oral form patients with Refractory Hypertension
  2. Hypertensive Emergency
    1. Nicardipine has replaced intravenous Labetalol for Hypertensive Emergency
      1. Difficult to achieve Blood Pressure control in Hypertensive Crisis despite titration
      2. Short acting
    2. Labetalol is a preferred agent when compared with Hydaralazine and Clonidine
  • Mechanism
  1. Combination of classes
    1. Alpha Adrenergic Antagonist and
    2. Nonselective Beta Blocker
  2. Primary activity is as a negative inotrope
    1. Chronotropic effect is mild
  • Dosing
  1. Oral: 100 mg PO bid (Maximum: 2400 mg/day)
  2. Intravenous: 20 mg IV q10 minutes (Maximum: 200 mg)