Pharm

Ibutilide

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Ibutilide, Corvert

  1. Time to Cardioversion: 1 hour
  2. Conversion Rate: 33-45% (60% in Atrial Flutter)
  • Mechanism
  1. Class III Antiarrhythmic
  • Dose
  1. Initial
    1. Under 60 kg: 0.01 mg/kg IV over 10 min
    2. Over 60 kg: 1 mg IV over 10 min
  2. Subsequent
    1. May repeat once after 10 min if not converted
  • Adverse Effects
  1. Observe QT Interval
  2. Evaluate Serum Potassium and Magnesium
  3. Significantly proarrhythmic
    1. Ventricular Tachycardia or fibrillation risk: 1-2%
    2. Requires EKG monitoring for 4 hours after dose
  • Precautions
  1. Most expensive Antiarrhythmic
  2. Cardiac monitor on starting agent
    1. Continue for minimum of 4 hours
    2. Continue until QT Interval normalizes