Pharm
Ibutilide
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Ibutilide
, Corvert
Indications
Atrial Fibrillation Cardioversion
Time to Cardioversion: 1 hour
Conversion Rate: 33-45% (60% in
Atrial Flutter
)
Mechanism
Class III
Antiarrhythmic
Dose
Initial
Under 60 kg: 0.01 mg/kg IV over 10 min
Over 60 kg: 1 mg IV over 10 min
Subsequent
May repeat once after 10 min if not converted
Adverse Effects
Observe
QT Interval
Evaluate
Serum Potassium
and
Magnesium
Significantly proarrhythmic
Ventricular Tachycardia
or fibrillation risk: 1-2%
Requires EKG monitoring for 4 hours after dose
Precautions
Most expensive
Antiarrhythmic
Cardiac monitor on starting agent
Continue for minimum of 4 hours
Continue until
QT Interval
normalizes
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