Pharm

Esmolol

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Esmolol, Esmolol Hydrochloride, Brevibloc

  • See Also
  1. Beta Blocker
  • Mechanism
  1. Selective Beta Blocker
  • Indications
  1. Atrial Fibrillation Rate Control
  2. Emergent Hypertension Management
  • Pharmacokinetics
  1. Half-Life: 9 minutes
    1. Rapidly metabolized by erythrocyte esterase
  2. Duration of action: 15-20 minutes
  • Dosing
  • Intravenous
  1. Preparation: 2.5g (10 ml ampule) in 250 ml (10 mg/ml)
  2. Load: 250-500 ug/kg over 1 min (70 kg: 35 mg, 3.5 ml)
  3. Infusion:
    1. Start 25-50 ug/kg/min IV (70 kg: 10 ml/h)
    2. Titrate up 25-50 ug/kg q5 min to max 300 ug/kg/min