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Clonidine Overdose
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Clonidine Overdose
, Clonidine Toxicity
See Also
Clonidine
Drug
Overdose
Alpha Adrenergic Central Agonist
Clonidine Withdrawal
Signs and Symptoms
Apnea
Bradycardia
Coma
Hypertension
or
Hypotension
Hypothermia
Mental status change
Pinpoint pupils (
Miosis
)
Management
Adults
Naloxone
Initial
No respiratory depression: 0.1 to 0.4 mg IV or IM
Respiratory depression: 1 to 2 mg IV or IM
Next, if no response or incomplete response
Give 2 mg IV or IM every 3-5 minutes to a total of 10-20 mg
Atropine
0.5 to 1 mg IV
Dopamine
5-20 mcg/kg/minute
Start low and titrate for effect
Management
Children
Naloxone
Initial
No respiratory depression: 0.1 mg/kg to 0.4 mg IV or IM
Respiratory depression: 1 to 2 mg IV or IM
Next, if no response or incomplete response
Give 2 mg IV or IM every 3-5 minutes to a total of 10-20 mg
Atropine
0.02 mg/kg up to 0.16 mg IV
Dopamine
5-20 mcg/kg/minute
Start low and titrate for effect
Add
Norepinephrine
if not responding to
Dopamine
at max dose
References
Seger (2002) J Toxicol Clin Toxicol 40(2): 145-55 [PubMed]
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