Pharm

Antiarrhythmic

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Antiarrhythmic, Vaughn Williams Classification

  • Preparations
  • Class I - Sodium Channel Blockade
  1. Class Ia: Lengthens action potential duration
    1. Quinidine
    2. Procainamide (Pronestyl)
    3. Disopyramide (Norpace)
    4. Amiodarone (also Class II, III, IV)
    5. Several non-classic Antiarrhythmics have Class Ia activity (e.g. Imipramine, a Tricyclic Antidepressant)
  2. Class Ib: Shortens action potential duration
    1. Lidocaine (Xylocaine)
    2. Tocainide (Tonocard)
    3. Mexiletine (Mexitil)
    4. Phenytoin (Dilantin)
  3. Class Ic: Slows conduction
    1. Flecainide (Tambocor)
    2. Encainide (Enkaid)
    3. Propafenone (Rythmol)
  1. Propranolol
  2. Metoprolol
  3. Atenolol
  4. Carvedilol (Coreg)
  5. Esmolol (Brevibloc)
  6. Sotalol (also Class III)
  7. Amiodarone (also Class Ia, III, IV)
  • Preparations
  • Class III - Blocks potassiun channels, prolongs repolarization
  1. Bretylium (Bretylol)
  2. Sotalol
  3. Amiodarone (also Class Ia, II, IV)
  4. Dofetilide (Tikosyn)
  5. Dronedarone (Multaq)
  1. Verapamil (Calan)
  2. Diltiazem (Cardizem)
  3. Nifedipine
  4. Amiodarone (also Class Ia, II, III)