Pharm

Acetazolamide

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Acetazolamide, Diamox

  • Mechanism
  1. Carbonic Anhydrase Inhibitor
  • Indications
  1. High Altitude Sickness treatment and prevention
  2. Pseudotumor Cerebri
  • Contraindications
  • Dosing
  1. High Altitude Sickness
    1. Prevention: 125 mg PO bid
      1. Start 24 hours before ascent
      2. Continue for 72 hours or until acclimitization to highest sleeping altitude
    2. Insomnia at altitude: 125 mg PO qhs
    3. Treatment: 250 mg orally twice daily (up to 400 mg twice daily has been sed)
  2. Pseudotumor Cerebri
    1. Dose range: 125-250 mg PO qd-tid
  • Adverse Effects
  1. Peripheral Paresthesias (common)
  2. Polyuria