Cardiovascular Medicine Book



Aka: Propranolol, Inderal
  1. See Also
    1. Beta Blocker
  2. Mechanism
    1. Non-Selective Beta Blocker
    2. Beta 1 Adrenergic ReceptorAntagonist
      1. Decreases Heart Rate, Cardiac Output, and Sympathetic System output (decreased renin release)
    3. Beta 2 Adrenergic ReceptorAntagonist
      1. Risk of bronchoconstriction
  3. Indications: Primary
    1. Hyperthyroidism
    2. Performance Anxiety
    3. Essential Tremor
    4. Migraine Headache Prophylaxis
  4. Indications: Selective Beta Blockers Preferred instead of Propranolol
    1. Hypertension
    2. Atrial Fibrillation Rate Control
  5. Adverse Effects
    1. See Beta Blocker
    2. Transient Hypertension
      1. Beta 2 Adrenergic ReceptorAntagonists transiently constrict large arteries
    3. CNS Adverse Effects
      1. CNS penetration
    4. Rebound Hypertension
      1. Sudden discontinuation of Propranolol
  6. Drug Interactions
    1. Cimetidine
      1. Increases Propanolol serum levels
  7. Dosing: Oral
    1. Regular: 40 mg PO bid (MAX: 640 mg/day)
    2. Extended: 80 mg PO qd (MAX: 320 mg/day)
  8. Dosing: Intravenous
    1. Load: 1-3 mg IV over 2-5 minutes
    2. Repeat every 2 minutes to a total dose of 0.1 mg/kg
    3. Sustained response for 6-8 hours
Medication Costs
propranolol (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
PROPRANOLOL 10 MG TABLET Generic $0.16 each
PROPRANOLOL 20 MG TABLET Generic $0.22 each
PROPRANOLOL 20 MG/5 ML SOLN Generic $0.09 per ml
PROPRANOLOL 40 MG TABLET Generic $0.25 each
PROPRANOLOL 60 MG TABLET Generic $0.63 each
PROPRANOLOL 80 MG TABLET Generic $0.47 each
PROPRANOLOL ER 120 MG CAPSULE Generic $1.58 each
PROPRANOLOL ER 160 MG CAPSULE Generic $2.40 each
PROPRANOLOL ER 60 MG CAPSULE Generic $1.02 each
PROPRANOLOL ER 80 MG CAPSULE Generic $1.32 each
inderal (on 1/1/2017 at Medicaid.Gov Pharmacy Drug pricing)
INDERAL XL 120 MG CAPSULE $22.30 each
INDERAL XL 80 MG CAPSULE $21.97 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Propranolol (C0033497)

Definition (NCI) A synthetic, nonselective beta-adrenergic receptor blocker with antianginal, antiarrhythmic, antihypertensive properties. Propranolol competitively antagonizes beta-adrenergic receptors, thereby causing negative chronotropic and inotropic effects leading to a reduction in cardiac output.
Definition (CSP) noncardioselective beta adrenergic antagonist; used in treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hyperthyroidism, migraine; pheochromocytoma, etc.
Definition (MSH) A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D011433
SnomedCT 372772003, 55745002
LNC LP16266-6, MTHU005037
English Propranolol, Propanolol, 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol, Propranolol [Chemical/Ingredient], propanolol, 1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol, PROPRANOLOL, propranolol, Propranolol (product), Propranolol (substance)
Swedish Propranolol
Czech propranolol
Finnish Propranololi
Japanese 塩酸プロプラノロール, アイデイトロール, インデラル, シンプラール, ソラシロール, メントリース, ノルモテンス, ラピノーゲン, サワタールLA, デキスプロプラノロール, プロパノロール, Tag錠, プロプラノロール
Polish Propranolol, Inderal
Spanish Propanolol, propranolol (producto), propranolol (sustancia), propranolol, Propranolol
Portuguese Propanolol, Propranolol
French Propranolol
German Propranolol
Italian Propanololo
Derived from the NIH UMLS (Unified Medical Language System)

Inderal (C0591636)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D011433
English inderal, Inderal
Derived from the NIH UMLS (Unified Medical Language System)

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