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Fibric Acid
Aka: Fibric Acid, Gemfibrozil, Clofibrate, Fenofibrate, Tricor, Trilipix- Efficacy
- Lipid effects
- Decreases Triglycerides (20-50%)
- Increases LDL Cholesterol (10-15%)
- Decreases VLDL Cholesterol
- Increases HDL Cholesterol (10-15%)
- Outcome effects
- No effect on all cause mortality
- NNT to prevent one coronary event: 46-125
- Lipid effects
- Adverse effects
- Gastrointestinal effects
- Gastrointestinal upset
- Abdominal Pain
- Higher rate of Gastrointestinal Disease
- Cholecystitis (increased risk by 2-3%)
- Appendicitis
- Miscellaneous
- Rash
- Renal dysfunction (rare)
- Myopathy (rare)
- Gastrointestinal effects
-
Drug Interactions
- May potentiate effects of:
- Coumadin
- Oral Hypoglycemic Agents
- May potentiate effects of:
- Contraindications
- Preparations
- Gemfibrozil (Lopid)
- Dose: 600 mg bid ($75/month)
- Fenofibrate (Tricor)
- Less likely to cause Rhabdomyolysis with Statin
- Fenofibrate (Trilipix)
- Rebranded version of Tricor in time for generic Fenofibrate release in 2011
- Clofibrate
- Discontinued in 2002
- Increased mortality from malignant and GI disease
- Gemfibrozil (Lopid)
- References
Medication Costs | ||
---|---|---|
gemfibrozil (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
GEMFIBROZIL 600 MG TABLET | Generic | $0.09 each |
fenofibrate (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
FENOFIBRATE 130 MG CAPSULE | Generic | $2.94 each |
FENOFIBRATE 134 MG CAPSULE | Generic | $1.01 each |
FENOFIBRATE 145 MG TABLET | Generic | $0.58 each |
FENOFIBRATE 150 MG CAPSULE | Generic | $5.56 each |
FENOFIBRATE 160 MG TABLET | Generic | $0.52 each |
FENOFIBRATE 200 MG CAPSULE | Generic | $1.75 each |
FENOFIBRATE 43 MG CAPSULE | Generic | $1.14 each |
FENOFIBRATE 48 MG TABLET | Generic | $0.42 each |
FENOFIBRATE 50 MG CAPSULE | Generic | $2.31 each |
FENOFIBRATE 54 MG TABLET | Generic | $0.39 each |
FENOFIBRATE 67 MG CAPSULE | Generic | $0.62 each |
tricor (on 3/22/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
TRICOR 145 MG TABLET | Generic | $0.58 each |
TRICOR 48 MG TABLET | Generic | $0.42 each |
trilipix (on 3/8/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
TRILIPIX DR 135 MG CAPSULE | Generic | $1.61 each |
TRILIPIX DR 45 MG CAPSULE | Generic | $0.89 each |
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. |
Clofibrate (C0009002) |
|
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Definition (NCI) | An aryloxyisobutyric acid derivate with antihyperlipidemic activity. Although the exact mechanism of action has not been fully characterized, clofibrate may enhance the conversion of very-low-density lipoprotein (VLDL) to low-density lipoprotein (LDL), decreasing the production of hepatic VLDL, inhibiting cholesterol production, and increasing fecal excretion of neutral sterols. |
Definition (MSH) | A fibric acid derivative used in the treatment of HYPERLIPOPROTEINEMIA TYPE III and severe HYPERTRIGLYCERIDEMIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986) |
Definition (CSP) | fibric acid derivative used in the treatment of hyperlipoproteinemia and hypertriglyceridemia. |
Definition (PDQ) | An aryloxyisobutyric acid derivate with antihyperlipidemic activity. Although the exact mechanism of action has not been fully characterized, clofibrate may enhance the conversion of very-low-density lipoprotein (VLDL) to low-density lipoprotein (LDL), decreasing the production of hepatic VLDL, inhibiting cholesterol production, and increasing fecal excretion of neutral sterols. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42108&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42108&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C378" NCI Thesaurus) |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D002994 |
SnomedCT | 387439004, 77035009 |
LNC | LP16082-7, MTHU016298 |
English | clofibrate, Chlorophenoxyisobutyrate, Ethyl, Ethyl Chlorophenoxyisobutyrate, Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, ethyl ester, 2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester, Ethyl 2-(4-Chlorophenoxy)-2-methylpropanoate, Ethyl p-Chlorophenoxyisobyturate, Clofibrate, CFB, clofibrate (medication), Clofibrate [Chemical/Ingredient], clofibrates, Clofibric Acid, Ethyl Ester, Clofibrate (product), Clofibrate (substance), CLOFIBRATE |
Swedish | Klofibrat |
Czech | klofibrát |
Finnish | Klofibraatti |
Russian | KLOFIBRAT, КЛОФИБРАТ |
Italian | Etil clorofenossi isobutirrato, Clofibrato |
Croatian | KLOFIBRAT |
Polish | Klofibrat |
Japanese | クロフィブレート, クロフィブラート |
Spanish | clofibrato (producto), clofibrato (sustancia), clofibrato, Clofibrato |
French | Clofibrate |
German | Clofibrat |
Portuguese | Clofibrato |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Gemfibrozil (C0017245) |
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Definition (NCI) | A fibric acid derivative with hypolipidemic effects. Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III results in subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C). |
Definition (MSH) | A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol. |
Definition (CSP) | lipid regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol. |
Concepts | Pharmacologic Substance (T121) , Lipid (T119) |
MSH | D015248 |
SnomedCT | 35282000, 387189002 |
LNC | LP15168-5, MTHU002557 |
English | Gemfibrozil, Gemfibrosil, Pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl-, gemfibrozil, gemfibrozil (medication), gemfibrozil (Lopid), GEMFIBROZIL, Gemfibrozil [Chemical/Ingredient], gemfibrosil, Gemfibrozil product, Gemfibrozil (product), Gemfibrozil (substance) |
Swedish | Gemfibrozil |
Czech | gemfibrozil |
Finnish | Gemfibrotsiili |
Russian | GEMFIBROZIL, ГЕМФИБРОЗИЛ |
Japanese | ジェムフィブロジィル, ゲムフィブロジル, ゲンフィブロジル |
Spanish | genfibrocil (producto), gemfibrozilo (producto), genfibrocil, Gemfibrozil, gemfibrozilo (sustancia), gemfibrozilo, gemfibrozil, genfibrocil (sustancia), Gemfibrozilo |
Italian | Gemfibrosil, Gemfibrozil |
French | Gemfibrosil, Gemfibrozil |
Polish | Gemfibrozil |
Croatian | Gemfibrozil |
Portuguese | Genfibrozil, Genfibrozila |
German | Gemfibrozil |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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