Urology Book

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Intraurethral Alprostadil

Aka: Intraurethral Alprostadil, MUSE
  1. Indications
    1. Psychogenic Impotence
    2. Neurogenic Impotence
    3. Vasculogenic Impotence
  2. Contraindications
    1. Penile deformity (e.g Peyronie's Disease)
    2. Sexual intercourse with pregnant women
      1. Risk of Preterm Labor
    3. Priapism risk
      1. Sickle Cell Disease or Sickle Cell Trait
      2. Leukemia
      3. Multiple Myeloma
      4. Polycythemia Vera
      5. Thrombocythemia
      6. Anticoagulant use
  3. Preparation
    1. Transurethral preparation
      1. Inserted 3 cm into Urethra with plastic applicator
    2. Semi-solid pellet
      1. Diameter: 1.4 mm
      2. Length: 3-6 mm
  4. Efficacy
    1. Successful intercourse in 65% of 1511 tested
    2. Placebo success rate: 19%
    3. Less effective than injectable alprostadil
  5. Adverse effects
    1. Hypotension (3%)
    2. Dizziness (2%)
    3. Mild Erectile discomfort (32%)
    4. Minor Urethral burning or bleeding
    5. Priapism is rare
  6. Dosing
    1. Dose 125-1000 ug ($114-$137 for 6 units)
  7. Reference
    1. Padma-Nathan (1997) N Engl J Med 336(1):1-7 [PubMed]
Medication Costs
muse (on 10/19/2016 at Medicaid.Gov Pharmacy Drug pricing)
MUSE 1,000 MCG URETHRAL SUPP $63.16 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Prostin VR (C0592016)

Concepts Pharmacologic Substance (T121) , Eicosanoid (T111)
MSH D000527
English Prostin VR Pediatric, prostin vr, prostin vr pediatric, Astra Brand of Alprostadil, Janssen Brand of Alprostadil, Prostin VR, Minprog, Prostine VR, AstraZeneca Brand of Alprostadil, Paladin Brand of Alprostadil, Pharmacia Brand 1 of Alprostadil, Vivus Brand of Alprostadil, Abbott Brand of Alprostadil
French Prostine VR
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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