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Intraurethral Alprostadil
Aka: Intraurethral Alprostadil, MUSE
- Indications
- Psychogenic Impotence
- Neurogenic Impotence
- Vasculogenic Impotence
- Contraindications
- Penile deformity (e.g Peyronie's Disease)
- Sexual intercourse with pregnant women
- Risk of Preterm Labor
- Priapism risk
- Sickle Cell Disease or Sickle Cell Trait
- Leukemia
- Multiple Myeloma
- Polycythemia Vera
- Thrombocythemia
- Anticoagulant use
- Preparation
- Transurethral preparation
- Inserted 3 cm into Urethra with plastic applicator
- Semi-solid pellet
- Diameter: 1.4 mm
- Length: 3-6 mm
- Efficacy
- Successful intercourse in 65% of 1511 tested
- Placebo success rate: 19%
- Less effective than injectable alprostadil
- Adverse effects
- Hypotension (3%)
- Dizziness (2%)
- Mild Erectile discomfort (32%)
- Minor Urethral burning or bleeding
- Priapism is rare
- Dosing
- Dose 125-1000 ug ($114-$137 for 6 units)
- Reference
- Padma-Nathan (1997) N Engl J Med 336(1):1-7 [PubMed]