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Apomorphine
Aka: Apomorphine, Uprima-
Mechanism
- Central acting, Dopaminergic agonist
- Pharmacokinetics
- Onset: 10 minutes
- Duration: 30 minutes
- Dose
- Uprima 2 to 6 mg SL
- Efficacy
- Effective in 55 to 60% of men (contrast 32% in Placebo)
- Adverse Effects (58% of men on 6 mg)
- Nausea (39%)
- Vomiting (10%)
- Dizziness (20%)
- Somnolence (11%)
- Sweaty (18%)
- Hypotension (4%)
- Syncope (2%)
Apomorphine (C0003596) |
|
|---|---|
| Definition (MSH) | A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use. |
| Definition (CSP) | derivative of morphine that is a dopamine D2 agonist; a powerful emetic useful in acute poisoning; has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D001058 |
| SnomedCT | 387375001, 67939000 |
| English | Apomorphine, 4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, (R)-, Apomorphine [Chemical/Ingredient], APOMORPHINE, Apomorphine (product), Apomorphine (substance), apomorphine |
| Swedish | Apomorfin |
| Czech | apomorfin |
| Finnish | Apomorfiini |
| Russian | APOMORFIN, АПОМОРФИН |
| Polish | Apomorfina |
| Japanese | アポモルフィン, アパフィナム, 塩酸アポモルヒネ, アポモルヒネ |
| Spanish | apomorfina (producto), apomorfina (sustancia), apomorfina, Apomorfina |
| French | Apomorphine |
| German | Apomorphin |
| Italian | Apomorfina |
| Portuguese | Apomorfina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Uprima (C1657321) |
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|---|---|
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| English | Uprima |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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