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Thiopental
Aka: Thiopental, Pentothal
- See Also
- Rapid Sequence Intubation
- Dose: Rapid Sequence Intubation
- Use lower dose if patient volume depleted
- Sedative Induction prior to intubation (RSI)
- Thiopental 3-5 mg/kg IVP
- Pharmacokinetics
- Onset: 1 min
- Duration: 10-30 min
- Indications: Sedation in Rapid Sequence Intubation (RSI)
- Largely replaced by newer agents for RSI (e.g. Etomidate, Ketamine)
- Situations where Thiopental might still be considered in RSI
- Status Epilepticus (Fast-acting anti-epileptic)
- Increased Intracranial Pressure (Fastest lowering of ICP of any induction agent)
- Contraindication
- Hypotension
- Asthma
- Congestive Heart Failure
- Porphyria
- Adverse Effects
- Hypotension
- Histamine release
- Skin necrosis if infiltrates (highly alkalotic agent with pH 10)